oenanthate and nandrolone decanoate for hypogonadisml6, hypopituitarism13, chronic renal failurel5 and generalized weaknessl5. The fact that castration palliates prostatic cancers suggests that testosterone may be involved in the genesis of these tumoursl7, and a number of epidemiological observations

Cases of benign hepatoma, peliosis hepatis, primary hepatocellular carcinoma and hepatic cholangiocarcinoma have aIl been linked to the use of androgenic steroids, mostly oxymetholonel-13. At least 25 cases ofliver-cell tumour have been reported in patients with Fanconi's anaemial-6,11,12, aplastie anaemial,4,7,8, paroxysmal nocturnal haemoglobinurial,12,13, panmyelopathy9 or megaloblastic anaemia10 treated with oxymetholone alone or in combination with other androgenic steroid drugs. Usually, treatment was given for years, but cancer has occurred within as little as two months of therapy6, and there have been